THEMIS2 — Thymocyte selection associated family member 2
THEMIS2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
THEMIS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Activated B cell B cell maturation | ARHGAP25, ARID3A, CFLAR, DUSP4, ENTPD1, MYO1F, PIK3R5, PLXNC1 +6 more | View in SCUBA |
| CD4⁺ T cells | Glycosylation & trafficking Protein processing & ER | AASDHPPT, ABHD12, ACTR1A, ANKRD35, AP1S1, ARRDC1, ATF6B, ATG5 +25 more | View in SCUBA |
| Macrophages | Macrophage Lipid Sensing Lipid metabolism | ARL4A, ARL4C, BIRC2, CES2, DDX21, DDX24, DDX27, GPR183 +12 more | View in SCUBA |
| Mucosal-associated invariant T cell | Chromatin Maintenance State DNA/chromatin regulation | ATRX, DYRK2, GART, KIF2A, PILRB, RBL2, S1PR5, SH2D1A +3 more | |
| Neutrophils | C5aR Complement Activation Innate immunity | ADGRG3, C5AR1, CD55, ITPRIP, LAPTM5, MCL1, PFKFB3, PTPRE +3 more |
About the gene
| Synonyms | C1orf38, ICB-1 |
|---|---|
| Chromosome | 1: 27872543-27886685 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Immunity, Inflammatory response |
Function
May constitute a control point in macrophage inflammatory response, promoting LPS-induced TLR4-mediated TNF production. Determines the threshold for activation of B cells by low-affinity and low-avidity ligands via PLCG2 activation and its downstream pathways (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.