Chromatin Maintenance State
Gene co-expression module in Mucosal-associated invariant T cell
| Category | DNA/chromatin regulation |
|---|---|
| Genes | 12 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include KIF2A (kinesin/microtubule), RBL2 (RB-like cell cycle repressor), ATRX (chromatin remodeler), DYRK2 (kinase regulating chromatin/cell cycle), and ZFP90 (zinc finger transcription factor). SH2D1A marks MAIT/NKT lineage identity and S1PR5 marks tissue egress competence. The dominant theme is DNA/chromatin regulation through RBL2, ATRX, DYRK2, KIF2A, and ZFP90, consistent with a quiescent chromatin-maintenance state. Neighbor M20 similarly features chromatin regulators (RBBP4, HDAC7, RUVBL1), reinforcing this chromatin regulatory neighborhood.
Genes
ATRX, DYRK2, GART, KIF2A, PILRB, RBL2, S1PR5, SH2D1A, THEMIS2, TMEM106B, TMEM63A, ZFP90
Most correlated modules
- Chemokine Receptor Migration · correlation 0.88
- Endosomal Actin Organization · correlation 0.85
- Mature Effector MAIT · correlation 0.84
- NF-κB Immune Survival · correlation 0.83
- Nuclear regulatory housekeeping · correlation 0.83
- Chromatin Complex Regulation · correlation 0.83
- MAIT Effector Maturation · correlation 0.81
- SWI/SNF Chromatin Remodeling · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.