SEMA4C — Semaphorin 4C
SEMA4C belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEMA4C's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Lymphocyte Tissue Egress migration & adhesion | ADRB2, ANTXR2, C1orf162, KLRG1, NSG1, RASSF3, RIPOR2, S1PR1 +7 more | |
| Macrophages | Stress Response Transcription Stress | AHR, C11orf96, CBX6, FAM110A, FN3K, GADD45A, LACC1, LPAR6 +8 more | View in SCUBA |
About the gene
| Synonyms | Semacl1, Semaf, SEMAI |
|---|---|
| Chromosome | 2: 96859718-96870757 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Neurogenesis |
Function
Cell surface receptor for PLXNB2 that plays an important role in cell-cell signaling. PLXNB2 binding promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'. Required for normal brain development, axon guidance and cell migration (By similarity). Probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.