S1PR1 — Sphingosine-1-phosphate receptor 1
S1PR1 belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
S1PR1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Naive B cell B cell maturation | ABCB1, ABCB4, BTLA, C1orf162, CD200, COL19A1, DSP, FCER2 +15 more | View in SCUBA |
| CD4⁺ T cells | Naive T quiescence T cell development | CCR7, CD55, CRIP2, CSGALNACT1, ITGA6, KLF2, KLF3, NOSIP +6 more | View in SCUBA |
| Endothelial | Integrin-Actin Adhesion migration & adhesion | APP, CHD3, CTNNA1, DAG1, DOCK6, FKBP9, FMNL3, ITGA9 +6 more | View in SCUBA |
| Gamma-delta T cells | Lymphocyte Tissue Egress migration & adhesion | ADRB2, ANTXR2, C1orf162, KLRG1, NSG1, RASSF3, RIPOR2, SAMD3 +7 more | |
| Lymphatic endothelial | Lymphatic Vascular Stability endothelial development | GJA1, GLT8D2, HIC1, HSD17B12, IGFBP4, KCTD12, MAF, ROBO4 +6 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mature Effector MAIT T cell maturation | ADD3, ANTKMT, APOBEC3G, CCL5, CXXC5, FHL3, GZMK, ITGA6 +7 more | |
| Natural Killer cells | Lymphocyte Trafficking Homing & TEM | BCL6, CTSD, LAPTM5, LITAF, ORAI1, P2RY8, PTPRJ, RNF166 +3 more | View in SCUBA |
About the gene
| Synonyms | CD363, D1S3362, edg-1, EDG1 |
|---|---|
| Chromosome | 1: 101236865-101243713 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Cancer-related genes, CD markers, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins, Transporters |
| Molecular function | G-protein coupled receptor, Receptor, Transducer |
| Biological process | Angiogenesis, Chemotaxis |
Function
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3- phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.