NSG1 — Neuronal vesicle trafficking associated 1
NSG1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
NSG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | WNT-modulating Fibroblast Developmental | CIB2, COL4A5, DMKN, F3, FIP1L1, FRZB, GPSM3, HSD17B2 +9 more | View in SCUBA |
| Gamma-delta T cells | Lymphocyte Tissue Egress migration & adhesion | ADRB2, ANTXR2, C1orf162, KLRG1, RASSF3, RIPOR2, S1PR1, SAMD3 +7 more | |
| Mucosal-associated invariant T cell | Cytoskeletal Remodeling Migration migration & adhesion | ADAM8, BIN2, C11orf21, CAPN1, CAPN2, CD52, CDC25B, CNN2 +14 more |
About the gene
| Synonyms | D4S234E, NEEP21, P21 |
|---|---|
| Chromosome | 4: 4348140-4419058 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
Function
Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway. Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (By similarity). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (By similarity). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.