KLRG1 — Killer cell lectin like receptor G1
KLRG1 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
KLRG1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADAM23, CTSW, EMP3, FKBP2, IFITM2, IGFBP3, LYAR, PLP2 +11 more | View in SCUBA |
| CD8⁺ T cells | Effector Memory CD8 T cell maturation | CLDND1, DENND2D, GIMAP1, GIMAP4, GIMAP7, GPR183, GZMK, ITM2C +3 more | View in SCUBA |
| Gamma-delta T cells | Lymphocyte Tissue Egress migration & adhesion | ADRB2, ANTXR2, C1orf162, NSG1, RASSF3, RIPOR2, S1PR1, SAMD3 +7 more | |
| Mucosal-associated invariant T cell | Mature Effector MAIT T cell maturation | ADD3, ANTKMT, APOBEC3G, CCL5, CXXC5, FHL3, GZMK, ITGA6 +7 more |
About the gene
| Synonyms | 2F1, CLEC15A, MAFA, MAFA-L |
|---|---|
| Chromosome | 12: 8950044-9010760 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Immunity, Innate immunity |
Function
Plays an inhibitory role on natural killer (NK) cells and T- cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E- cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.