Lymphocyte Tissue Egress
Gene co-expression module in Gamma-delta T cells
| Category | migration & adhesion |
|---|---|
| Genes | 16 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 16 genes have a known function matching the annotation |
Why this annotation
The top hub genes SELL (CD62L, L-selectin for lymph node homing) and S1PR1 (sphingosine-1-phosphate receptor 1, required for lymphocyte egress from lymphoid organs) are the canonical markers of naive/recirculating T cells and tissue egress. KLRG1 marks terminally differentiated effector cells with high migratory capacity. RIPOR2 (RHOBTB3-related, regulates lymphocyte migration), ADRB2 (beta-2 adrenergic receptor, modulates lymphocyte trafficking), SAMD3, ST6GAL1 (sialylation of CD62L), and SEMA4C support a lymphocyte tissue egress and recirculation program. This module likely marks γδ T cells in a naive or recently egressed recirculating state.
Genes
ADRB2, ANTXR2, C1orf162, KLRG1, NSG1, RASSF3, RIPOR2, S1PR1, SAMD3, SELL, SEMA4C, SMIM14, ST6GAL1, STMN3, TC2N, THEM4
Most correlated modules
- Coinhibitory Checkpoint · correlation 0.91
- TCR Proximal Signaling · correlation 0.89
- Death Receptor Apoptosis · correlation 0.86
- Effector IFN Response · correlation 0.85
- γδ T Cell Identity · correlation 0.80
- Effector Cell Migration · correlation 0.80
- Immune Synapse Cytoskeleton · correlation 0.79
- T Cell Survival · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.