SEMA6B — Semaphorin 6B
SEMA6B belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SEMA6B's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Basement Membrane Assembly ECM remodeling | COL15A1, COL4A1, COL4A2, HSPG2, KIFC3, MGAT4A, NDST1, NOL4L +4 more | View in SCUBA |
| Macrophages | Lipid-Sensing Transcriptional Lipid metabolism | ANKLE2, BAIAP2, C19orf25, C1orf52, COX19, CWC25, DEDD2, DNTTIP2 +29 more | View in SCUBA |
| Monocytes | Endosomal Sorting Vesicular traficking | FPGS, GAB2, GGA2, HGS, MAFG, PIK3R5, SSH1, TPRA1 +1 more | View in SCUBA |
About the gene
| Synonyms | SEM-SEMA-Z, SEMA-VIB, SEMAN, semaZ |
|---|---|
| Chromosome | 19: 4542593-4581776 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted membrane proteins |
| Molecular function | Developmental protein |
| Biological process | Differentiation, Neurogenesis |
Function
Functions as a cell surface repellent for mossy fibers of developing neurons in the hippocampus where it plays a role in axon guidance. May function through the PLXNA4 receptor expressed by mossy cell axons. (Microbial infection) Acts as a receptor for P.sordellii toxin TcsL in the in the vascular endothelium
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.