ANKLE2 — Ankyrin repeat and LEM domain containing 2
ANKLE2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ANKLE2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Lymphatic endothelial | NF-κB Inflammatory Activation Inflammation | ACHE, CD200, CXCL1, CXCL8, HMGA1, ICOSLG, NFKB2, NOD2 +9 more | View in SCUBA |
| Macrophages | Lipid-Sensing Transcriptional Lipid metabolism | BAIAP2, C19orf25, C1orf52, COX19, CWC25, DEDD2, DNTTIP2, FBRS +29 more | View in SCUBA |
About the gene
| Synonyms | KIAA0692, Lem4, LEMD7 |
|---|---|
| Chromosome | 12: 132725503-132761832 |
| Predicted location | Intracellular, Membrane |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Cell cycle, Cell division, Mitosis |
Function
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non- dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.