DEDD2 — Death effector domain containing 2
DEDD2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DEDD2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Heat Shock Response Stress | BAG3, CHORDC1, DDIT4, DNAJA4, DNAJB1, DNAJB4, DNAJB6, EIF5 +13 more | View in SCUBA |
| CD4⁺ T cells | Heat Shock Response Stress | ANKRD37, CHORDC1, DNAJA1, DNAJA4, DNAJB1, DNAJB4, HSP90AA1, HSP90AB1 +12 more | View in SCUBA |
| Gamma-delta T cells | RNA Binding/Splicing RNA processing & translation | AIMP1, ATP11B, C1orf43, CCT2, DGKD, ENSA, ENY2, FBXL14 +18 more | |
| Innate lymphoid cells | Heat Shock Response Stress | AHSA1, ANKRD37, DNAJB1, DNAJB4, HSP90AA1, HSP90AB1, HSPA1A, HSPA1B +9 more | View in SCUBA |
| Lymphatic endothelial | Notch TGF-β Endothelial endothelial development | ARF6, ARL4C, C16orf87, CCNL1, CLK1, ELOC, GPBP1, HEY1 +11 more | View in SCUBA |
| Macrophages | Lipid-Sensing Transcriptional Lipid metabolism | ANKLE2, BAIAP2, C19orf25, C1orf52, COX19, CWC25, DNTTIP2, FBRS +29 more | View in SCUBA |
About the gene
| Synonyms | FLAME-3 |
|---|---|
| Chromosome | 19: 42198598-42220140 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding |
| Biological process | Apoptosis, Transcription, Transcription regulation |
Function
May play a critical role in death receptor-induced apoptosis and may target CASP8 and CASP10 to the nucleus. May regulate degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.