Basement Membrane Assembly
Gene co-expression module in Endothelial
| Category | ECM remodeling |
|---|---|
| Genes | 13 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
This module is tightly centered on basement membrane (BM) structural components: COL4A1 and COL4A2 (type IV collagen, core BM scaffold), COL15A1 (type XV collagen, endothelial BM), HSPG2 (perlecan, major BM heparan sulfate proteoglycan), SPARC (matricellular glycoprotein regulating BM assembly), VWA1 (von Willebrand factor A domain, BM), NDST1 (heparan sulfate N-deacetylase/N-sulfotransferase, HS biosynthesis), MGAT4A (N-glycan branching). All hub genes are core members. The modest but significant inflammation upregulation may reflect BM remodeling during colitis. This is a constitutive endothelial basement membrane maintenance program.
Genes
COL15A1, COL4A1, COL4A2, HSPG2, KIFC3, MGAT4A, NDST1, NOL4L, ORAI2, RFLNB, SEMA6B, SPARC, VWA1
Most correlated modules
- Vascular Barrier Integrity · correlation 0.89
- Inflammatory EC Activation · correlation 0.85
- Angiogenic Endothelial Identity · correlation 0.83
- Coagulation Protease Signaling · correlation 0.82
- Venous Endothelial Identity · correlation 0.82
- ECM Fibrotic Remodeling · correlation 0.78
- VEGF Tip Cell Signaling · correlation 0.77
- Arterial EC Identity · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.