COL4A2 — Collagen type IV alpha 2 chain
COL4A2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COL4A2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Basement Membrane Assembly ECM remodeling | COL15A1, COL4A1, HSPG2, KIFC3, MGAT4A, NDST1, NOL4L, ORAI2 +4 more | View in SCUBA |
| Fibroblasts | Focal Adhesion ECM Migration & adhesion | ACTN1, CLIC4, COL4A1, MPRIP, MRPL33, MYL6, NDUFA4, PARVA +6 more | View in SCUBA |
| Glial cells | Collagen ECM Deposition ECM remodeling | COL15A1, COL18A1, COL1A1, COL28A1, COL4A1, COL5A2, COL6A2, FLNA +2 more | View in SCUBA |
| Lymphatic endothelial | Basement Membrane ECM migration & adhesion | BRD4, COL4A1, GOLGA4, ITGAV, PITPNB, PXDN, RAI14, RB1CC1 +4 more | View in SCUBA |
| Pericytes | BM Collagen Production ECM production | ANGPT2, COL18A1, COL4A1, COL5A3, ITGA1, MEST, PXDN, SPARC | View in SCUBA |
| Smooth muscle cells | Collagen Biosynthesis ECM remodeling | CALU, COL1A1, COL1A2, COL3A1, COL4A1, COL6A1, COL6A2, EMILIN1 +4 more | View in SCUBA |
About the gene
| Synonyms | DKFZp686I14213, FLJ22259 |
|---|---|
| Chromosome | 13: 110305812-110513209 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Angiogenesis |
Function
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Canstatin, a cleavage product corresponding to the collagen alpha 2(IV) NC1 domain, possesses both anti-angiogenic and anti-tumor cell activity. It inhibits proliferation and migration of endothelial cells, reduces mitochondrial membrane potential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity. Ligand for alphavbeta3 and alphavbeta5 integrins
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.