Lipid-Sensing Transcriptional
Gene co-expression module in Macrophages
| Category | Lipid metabolism |
|---|---|
| Genes | 38 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 10 of 38 genes have a known function matching the annotation |
Why this annotation
Top hub genes include MAFG (NRF2 pathway transcription factor), INSIG1 (insulin-induced gene, cholesterol/sterol sensor in ER), POR (cytochrome P450 oxidoreductase, lipid/sterol metabolism), JMJD6 (epigenetic arginine demethylase), KLF13 (KLF transcription factor), TIPARP (PARP family stress response), GABARAPL1 (autophagy receptor), NFKBIB (IκBζ, NF-κB inhibitor). MAFG+INSIG1+POR together point toward lipid/cholesterol metabolism regulation. NFKBIB and TIPARP suggest inflammatory modulation. The module is weakly coherent with all genes showing weak membership, suggesting a mixed transcriptional regulatory program centered on lipid sensing and NF-κB modulation in monocyte-macrophages.
Genes
ANKLE2, BAIAP2, C19orf25, C1orf52, COX19, CWC25, DEDD2, DNTTIP2, FBRS, GABARAPL1, INSIG1, JMJD6, KLF13, KLHL21, LDLR, MAFG, MAN2A2, MEFV, NCBP3, NFKBIB, NOTCH1, ORAI2, PIM3, PMEPA1, POR, PPIF, RHBDD2, RUNX3, SEMA6B, SERTAD1, SIRT7, SLC43A2, SQSTM1, THBS1, TIPARP, TRIM25, ZBTB43, ZFYVE16
Most correlated modules
- Transcriptional Elongation · correlation 0.94
- mRNA Splicing Processing · correlation 0.93
- ER Protein Translocation · correlation 0.88
- Integrated Stress Response · correlation 0.86
- NRF2 Oxidative Stress · correlation 0.85
- Osmotic Stress Response · correlation 0.84
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.