BCR Signaling Regulation
Gene co-expression module in CD19⁺ B cells
| Category | BCR/AP1/NFKb pathway |
|---|---|
| Genes | 14 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 14 genes have a known function matching the annotation |
Why this annotation
This module is strongly B-cell immune-regulatory: PTPN22 (negative regulator of antigen receptor signaling), FCRL3 and FCRL2 (Fc receptor-like, B cell regulatory receptors), SIGLEC10 (inhibitory receptor), CBLB (E3 ligase dampening lymphocyte activation), CYTIP, TAGAP, ORAI2 (calcium entry for BCR signaling). The signature is a coherent BCR signaling/immune receptor regulation program in B cells. FCRL2/FCRL3 and SIGLEC10 are B-cell maturation/regulation markers.
Genes
CBLB, CYTIP, FCRL2, FCRL3, G3BP2, HIVEP1, ITPR2, IVNS1ABP, MOB3A, ORAI2, PTPN22, RBBP6, SIGLEC10, TAGAP
Most correlated modules
- Leukocyte Migration Signaling · correlation 0.92
- Chromatin Modification · correlation 0.84
- Chromatin modifiers · correlation 0.83
- B-cell signaling regulators · correlation 0.83
- B Cell Identity Signaling · correlation 0.82
- B-cell activation · correlation 0.76
- Oxidative/ER stress · correlation 0.73
- B-cell signaling regulators · correlation 0.73
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.