ITPR2 — Inositol 1,4,5-trisphosphate receptor type 2
ITPR2 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ITPR2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | BCR Signaling Regulation BCR/AP1/NFKb pathway | CBLB, CYTIP, FCRL2, FCRL3, G3BP2, HIVEP1, IVNS1ABP, MOB3A +5 more | View in SCUBA |
| Endothelial | Arterial EC Identity Endothelial cell development | AFAP1L2, BMP4, CFAP36, FUT8, JAG1, LTBP4, NEBL, NPTXR +6 more | View in SCUBA |
| Gamma-delta T cells | Post-transcriptional RNA Regulation RNA processing & translation | CCNG1, DHX15, FUBP1, HNRNPA3, IPO7, OSBPL3, PLEKHB2, SP140 | |
| Goblet cells | Goblet Cell Identity Epithelial development | CELF2, FOXP1, FRYL, GPRIN3, HOXB13, KCTD12, NEDD4L, NFAT5 +5 more | View in SCUBA |
| Macrophages | ER Stress Response Stress | ARHGEF12, ATXN7, BTBD7, CD2AP, CLIP2, DAPK1, DST, ERN1 +14 more | View in SCUBA |
| Mucosal-associated invariant T cell | Calcium Signal Integration TCR Signaling | ANKRD44, ARB2A, CAMK2D, DOCK10, ELMO1, EXOC4, FCHSD2, FNDC3A +20 more |
About the gene
| Synonyms | CFAP48, IP3R2 |
|---|---|
| Chromosome | 12: 26335352-26833194 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Calcium channel, Ion channel, Ligand-gated ion channel, Receptor |
| Biological process | Calcium transport, Ion transport, Transport |
Function
Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long- lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.