SCUBA

ST3GAL5 — ST3 beta-galactoside alpha-2,3-sialyltransferase 5

ST3GAL5 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

ST3GAL5's module in each cell type

Cell typeModuleShares the module with
CD4⁺ T cellsInflammatory activation
Immune regulation		ATF7IP2, ATP10D, B3GALT2, COMMD8, GBP3, GFI1, GPR34, MAEA +7 moreView in SCUBA
Innate lymphoid cellsTranscriptional Regulation
DNA regulation & transcription		ACAA1, ATRX, C1orf43, CARHSP1, CHTOP, CTDSP1, CTR9, DRAP1 +18 moreView in SCUBA
MacrophagesAntiviral ISG Response
Antiviral		ADAR, APOL6, ARID5A, CLEC7A, DDX60, DTX3L, EIF2AK2, ERICH1 +29 moreView in SCUBA

About the gene

SynonymsSIAT9, SIATGM3S, ST3GalV
Chromosome2: 85837120-85905199
Predicted locationIntracellular, Membrane
Essential geneNo
Protein classDisease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins
Molecular functionGlycosyltransferase, Transferase
Biological processLipid metabolism

Function

Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the non-reducing terminal galactose (Gal) of glycosphingolipids forming gangliosides (important molecules involved in the regulation of multiple cellular processes, including cell proliferation and differentiation, apoptosis, embryogenesis, development, and oncogenesis). Mainly involved in the biosynthesis of ganglioside GM3 but can also use different glycolipids as substrate acceptors such as D- galactosylceramide (GalCer), asialo-GM2 (GA2) and asialo-GM1 (GA1), although less preferentially than beta-D-Gal-(1->4)-beta-D-Glc-(1<->1)- Cer (LacCer).

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.