Transcriptional Regulation
Gene co-expression module in Innate lymphoid cells
| Category | DNA regulation & transcription |
|---|---|
| Genes | 27 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 20 genes have a known function matching the annotation |
Why this annotation
Hub genes include GTF2I (general transcription factor II-I, also involved in Williams syndrome and immune regulation), RAB37 (small GTPase, vesicle trafficking), MRPL43 (mitochondrial ribosomal protein), TOX2 (transcription factor, lymphocyte development), PSIP1 (LEDGF, chromatin/transcription), SREK1 (splicing regulator), PPP2R5A (PP2A regulatory subunit), VPS35 (retromer complex, endosomal sorting), CARHSP1 (mRNA stability), SPOP (E3 ubiquitin ligase adaptor), OGA (O-GlcNAcase), DRAP1 (transcriptional repressor), ELOVL6 (fatty acid elongase), MBP (myelin basic protein - likely non-canonical expression), NMT2 (N-myristoyltransferase). The module is weakly coherent with mostly weak membership. The combination of transcriptional regulators (GTF2I, TOX2, PSIP1, DRAP1), splicing (SREK1), and metabolic enzymes (ELOVL6, NMT2, OGA) without a clear dominant pathway suggests a general transcriptional regulation program. TOX2 and GTF2I are notable for lymphocyte differentiation. Neighbor context: similar to M40 and M11 in being broadly expressed with mixed programs.
Genes
ACAA1, ATRX, C1orf43, CARHSP1, CHTOP, CTDSP1, CTR9, DRAP1, ELOVL6, GTF2I, MBP, MRPL43, NFATC1, NMT2, OGA, PPP2R5A, PSIP1, RAB37, SPG7, SPOP, SREK1, ST3GAL5, STARD3NL, TMEM219, TOX2, TRAPPC6A, VPS35
Most correlated modules
- Transcription RNA Processing · correlation 0.92
- NK Cytotoxic Regulation · correlation 0.89
- Actin Cytoskeleton Dynamics · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.