COL18A1 — Collagen type XVIII alpha 1 chain
COL18A1 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
COL18A1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | ECM Fibrotic Remodeling ECM remodeling | ADAMTS7, ANGPTL2, CD276, CETP, COLGALT1, DDI2, ERO1A, LBH +7 more | View in SCUBA |
| Fibroblasts | CCL11 Secretory Fibroblast ECM production | ANK3, ARHGAP24, CCL11, COL16A1, DTX4, F11R, GABRA2, KAZN +5 more | View in SCUBA |
| Glial cells | Collagen ECM Deposition ECM remodeling | COL15A1, COL1A1, COL28A1, COL4A1, COL4A2, COL5A2, COL6A2, FLNA +2 more | View in SCUBA |
| Pericytes | BM Collagen Production ECM production | ANGPT2, COL4A1, COL4A2, COL5A3, ITGA1, MEST, PXDN, SPARC | View in SCUBA |
| Smooth muscle cells | Pericyte Basement Membrane ECM remodeling | ACAN, ADCY6, ANGPT1, ATP8B1, CSPG4, ENTPD1, HIP1, ITGA3 +7 more | View in SCUBA |
About the gene
| Synonyms | KNO, KNO1, KS |
|---|---|
| Chromosome | 21: 45405165-45513720 |
| Predicted location | Intracellular, Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins |
| Biological process | Cell adhesion |
Function
Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube. May regulate extracellular matrix-dependent motility and morphogenesis of endothelial and non- endothelial cells; the function requires homotrimerization and implicates MAPK signaling. Potently inhibits endothelial cell proliferation and angiogenesis. May inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling (By similarity). Inhibits VEGFA-induced endothelial cell proliferation and migration. Seems to inhibit VEGFA- mediated signaling by blocking the interaction of VEGFA to its receptor KDR/VEGFR2. Modulates endothelial cell migration in an integrin- dependent manner implicating integrin ITGA5:ITGB1 and to a lesser extent ITGAV:ITGB3 and ITGAV:ITGB5 (By similarity). May negatively regulate the activity of homotrimeric non-collagenous domain 1.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.