CSPG4 — Chondroitin sulfate proteoglycan 4
CSPG4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
CSPG4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Pericytes | Pericyte Vascular Tone Developmental | ADAP2, CHCHD10, FOXS1, LINGO1, MCAM, MFGE8, PGF, PTGIR +3 more | View in SCUBA |
| Smooth muscle cells | Pericyte Basement Membrane ECM remodeling | ACAN, ADCY6, ANGPT1, ATP8B1, COL18A1, ENTPD1, HIP1, ITGA3 +7 more | View in SCUBA |
About the gene
| Synonyms | CSPG4A, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2 |
|---|---|
| Chromosome | 15: 75674322-75712848 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Predicted membrane proteins |
| Molecular function | Developmental protein, Transducer |
| Biological process | Angiogenesis, Differentiation, Tissue remodeling |
Function
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Also functions as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.