SWAP70 — Switching B cell complex subunit SWAP70
SWAP70 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SWAP70's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Junction Identity Endothelial cell development | ADGRF5, AKAP13, CDH5, CXCL12, DENND5A, FGF12, FURIN, HSPA12B +13 more | View in SCUBA |
| Macrophages | General Cellular Maintenance Housekeeping | ABHD13, AKT2, AMD1, C1GALT1, DCUN1D1, FBXL3, FMR1, GAK +13 more | View in SCUBA |
About the gene
| Synonyms | KIAA0640, SWAP-70 |
|---|---|
| Chromosome | 11: 9664077-9752993 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | DNA-binding |
Function
Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.