Endothelial Junction Identity
Gene co-expression module in Endothelial
| Category | Endothelial cell development |
|---|---|
| Genes | 22 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 14 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes CDH5 (VE-cadherin), PODXL (podocalyxin), ADGRF5 (endothelial GPCR), and RAPGEF1/SWAP70/RASGRF2 (GEFs regulating Rap/Rac at junctions) define a quiescent endothelial junction maintenance program. AKAP13 links PKA to Rho signaling at junctions, CXCL12 is expressed by quiescent endothelium, and HSPA12B is endothelial-specific. ZEB1 and NES suggest a mesenchymal-competent endothelial state. Uniform expression across subsets and slight upregulation in UC remission support a homeostatic endothelial identity program. Neighbor context: consistent with M43 and M124 as endothelial identity modules in this batch.
Genes
ADGRF5, AKAP13, CDH5, CXCL12, DENND5A, FGF12, FURIN, HSPA12B, NES, PIK3R3, PLPP1, PODXL, PTK2, RAPGEF1, RASGRF2, RFTN1, SWAP70, SYNPO, TBC1D1, TMEM184B, VOPP1, ZEB1
Most correlated modules
- Inflammatory Angiogenic Activation · correlation 0.91
- Endothelial Angiogenic Identity · correlation 0.88
- Integrin-Actin Adhesion · correlation 0.88
- Mitophagy Stress Response · correlation 0.88
- WAVE Complex Cytoskeleton · correlation 0.87
- Endocytic Membrane Remodeling · correlation 0.86
- Arterial EC Identity · correlation 0.84
- Venous Endothelial Identity · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.