DENND5A — DENN domain containing 5A
DENND5A belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
DENND5A's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Endothelial | Endothelial Junction Identity Endothelial cell development | ADGRF5, AKAP13, CDH5, CXCL12, FGF12, FURIN, HSPA12B, NES +13 more | View in SCUBA |
| Lymphatic endothelial | NF-κB Innate Signaling Inflammation | AKAP13, B4GALT5, BACH1, CHD2, CNST, HIVEP1, HIVEP2, IRAK2 +11 more | View in SCUBA |
| Macrophages | Alternative Activation Lipid Lipid metabolism | ACSL1, ADCY3, AGFG1, ARHGEF10L, ARID5B, ATP2B4, BCL6, CCL13 +24 more | View in SCUBA |
| Monocytes | Non-canonical NF-κB Innate immunity | AMPD2, BCL3, BEST1, FAM20A, NFKB2, NOCT, RELB, TICAM1 | View in SCUBA |
| Neutrophils | NF-κB Inflammatory Transcription Inflammatory | BID, C9orf72, ELL2, ETF1, N4BP1, NFE2L2, NFKB1, OXSR1 +10 more |
About the gene
| Synonyms | FLJ22354, FLJ33829, FLJ43455, KIAA1091, RAB6IP1 |
|---|---|
| Chromosome | 11: 9138825-9265959 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Guanine-nucleotide releasing factor |
Function
Guanine nucleotide exchange factor (GEF) which may activate RAB6A and RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Involved in the negative regulation of neurite outgrowth (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.