TLE2 — TLE family member 2, transcriptional corepressor
TLE2 belongs to a gene co-expression module in 1 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TLE2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Smooth muscle cells | Pericyte Vasoregulatory Identity Contractility | ABCC9, ADRA2C, CCDC80, CFH, FEZ2, FGF7, KCNJ8, PCSK1N +6 more | View in SCUBA |
About the gene
| Synonyms | ESG, ESG2, FLJ41188, GRG2 |
|---|---|
| Chromosome | 19: 2997639-3047635 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Repressor |
| Biological process | Transcription, Transcription regulation, Wnt signaling pathway |
Function
Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full- length TLE family members may be modulated by association with dominant-negative AES (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.