PCSK1N — Proprotein convertase subtilisin/kexin type 1 inhibitor
PCSK1N belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PCSK1N's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Glial cells | Enteric Glial Homeostasis Housekeeping | APOE, BCHE, CCND3, COL12A1, ENTPD2, FXYD6, NPDC1, PAQR6 +5 more | View in SCUBA |
| Smooth muscle cells | Pericyte Vasoregulatory Identity Contractility | ABCC9, ADRA2C, CCDC80, CFH, FEZ2, FGF7, KCNJ8, PROS1 +6 more | View in SCUBA |
About the gene
| Synonyms | BigLEN, PEN, proSAAS, SAAS, SCG8, SgVIII |
|---|---|
| Chromosome | X: 48831096-48835610 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Predicted secreted proteins |
| Molecular function | Neuropeptide |
Function
May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the further processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity (By similarity). Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.