ABCC9 — ATP binding cassette subfamily C member 9
ABCC9 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ABCC9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | ICC niche interactaion Gut motility | ADGRF5, ANO1, CD36, CFHR1, ESAM, FHL5, HOPX, HRH2 +10 more | View in SCUBA |
| Pericytes | Pericyte Identity Cytoskeletal | ARHGAP42, ARHGEF17, ECM2, EDNRA, EGFLAM, GJC1, LHFPL6, MYO1B +2 more | View in SCUBA |
| Smooth muscle cells | Pericyte Vasoregulatory Identity Contractility | ADRA2C, CCDC80, CFH, FEZ2, FGF7, KCNJ8, PCSK1N, PROS1 +6 more | View in SCUBA |
About the gene
| Synonyms | CMD1O, SUR2 |
|---|---|
| Chromosome | 12: 21797389-21942543 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Disease related genes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, Transporters |
| Molecular function | Receptor |
| Biological process | Transport |
Function
Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. Can form a sulfonylurea-sensitive but ATP-insensitive potassium channel with KCNJ8 (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.