TLR10 — Toll like receptor 10
TLR10 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TLR10's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Lymphoid signaling regulators BCR/AP1/NFKb pathway | CCDC88B, FGD2, IKZF1, LENG8, MACF1, OGT, PCSK7, PHYKPL +4 more | View in SCUBA |
| Hematopoietic progenitor cells | Myeloid Innate Immune Myeloid development | CCR2, CUX2, CYBB, FXYD7, KCNC3, KIF17, NFKB1, PLD4 +5 more |
About the gene
| Synonyms | CD290 |
|---|---|
| Chromosome | 4: 38772238-38782990 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Receptor |
| Biological process | Immunity, Inflammatory response, Innate immunity |
Function
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.