Lymphoid signaling regulators
Gene co-expression module in CD19⁺ B cells
| Category | BCR/AP1/NFKb pathway |
|---|---|
| Genes | 13 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 13 genes have a known function matching the annotation |
Why this annotation
Module contains lymphoid transcription factors and signaling: IKZF1 (Ikaros, key B/lymphoid TF), FGD2 (Rho-GEF in immune cells), CCDC88B (immune cell migration), TLR10 (B-cell expressed TLR), OGT (O-GlcNAc), PCSK7, SETBP1. The IKZF1/FGD2/TLR10/CCDC88B combination points to a B/lymphoid signaling and regulation program. Disease-associated with strong CD inflammation signal.
Genes
CCDC88B, FGD2, IKZF1, LENG8, MACF1, OGT, PCSK7, PHYKPL, PNISR, SETBP1, SLC12A9, TLR10, TTN
Most correlated modules
- B-cell antigen presentation · correlation 0.88
- B-cell signaling regulators · correlation 0.84
- Chromatin & genome maintenance · correlation 0.84
- B-cell activation · correlation 0.78
- mRNA splicing · correlation 0.77
- Chromatin modifiers · correlation 0.76
- Atypical memory B cell · correlation 0.72
- Interferon Response · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.