PCSK7 — Proprotein convertase subtilisin/kexin type 7
PCSK7 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PCSK7's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | Lymphoid signaling regulators BCR/AP1/NFKb pathway | CCDC88B, FGD2, IKZF1, LENG8, MACF1, OGT, PHYKPL, PNISR +4 more | View in SCUBA |
| Macrophages | RNA Splicing Processing Housekeeping | ARMCX3, CIRBP, ELK4, GATAD1, H3-3B, HNRNPA2B1, HNRNPA3, HNRNPL +13 more | View in SCUBA |
| Mucosal-associated invariant T cell | RNA Splicing Processing RNA processing & translation | CCDC88B, EHBP1L1, EIF3A, GAB3, KDM5A, KIDINS220, LIX1L, SCAF11 +4 more |
About the gene
| Synonyms | LPC, PC7, PC8, SPC7 |
|---|---|
| Chromosome | 11: 117204337-117232525 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins, Predicted membrane proteins |
| Molecular function | Hydrolase, Protease, Serine protease |
Function
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.