TRAPPC4 — Trafficking protein particle complex subunit 4
TRAPPC4 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRAPPC4's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Innate lymphoid cells | DNA Damage Response Stress | ANP32E, CCT6A, CLTB, FGFR1OP2, GNL3, HNRNPF, JPT1, MRPS6 +7 more | View in SCUBA |
| Macrophages | ERAD Proteasome Housekeeping | ADRM1, EIF6, EMC6, GLRX3, GNPTG, LRPAP1, MAP2K2, MED8 +16 more | View in SCUBA |
About the gene
| Synonyms | PTD009, SBDN, TRS23 |
|---|---|
| Chromosome | 11: 119018763-119025454 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Disease related genes, Essential proteins, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | ER-Golgi transport, Transport |
Function
Core component of the TRAPP complexes which has a function of guanine nucleotide exchange factor activity for Rab1 GTPase (Probable). Plays a role in vesicular transport from endoplasmic reticulum to Golgi and autophagy. May play a role in dendrite postsynaptic membrane trafficking (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.