SCUBA

CCT6A — Chaperonin containing TCP1 subunit 6A

CCT6A belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

CCT6A's module in each cell type

Cell typeModuleShares the module with
CD19⁺ B cellsChaperonin Protein Folding
Protein processing & ER
BANF1, CCT2, CCT3, CCT4, CCT5, EIF2S1, ILF2, MRPL14 +5 moreView in SCUBA
CD4⁺ T cellsT cell activation
TCR/AP1/NFKb pathway
ANKS1B, ARF6, EHD4, HNRNPM, IRF4, MAP2K3, PFDN2, TRIB1 +3 moreView in SCUBA
CD8⁺ T cellsRNA & Redox Housekeeping
RNA processing & translation
ANP32A, C11orf58, COPRS, DPM2, GGCT, GLRX3, LAGE3, NME1 +3 moreView in SCUBA
EndothelialmRNA Splicing Stress
RNA processing & translation
CCDC50, FAM114A1, GLRX3, PPM1G, RTRAF, SRSF9, TXNL4A, YWHAEView in SCUBA
Gamma-delta T cellsProteostasis/Chaperonin
Protein processing & ER
BST2, CARD16, CBR1, CCT3, DOK2, DYNLL1, HIKESHI, ME2 +13 more
Goblet cellsCCT Chaperonin Complex
Protein processing & ER
CCT5, HDGF, HNRNPA3, HNRNPC, IDH2, PTGES3, SMS, SRP9 +2 moreView in SCUBA
Hematopoietic progenitor cellsChaperonin TRiC Complex
Housekeeping
ARL2, CCDC85B, CCT2, CCT3, CCT5, GADD45GIP1, NDUFS5, NUDC +4 more
Innate lymphoid cellsDNA Damage Response
Stress
ANP32E, CLTB, FGFR1OP2, GNL3, HNRNPF, JPT1, MRPS6, PDCD10 +7 moreView in SCUBA
MacrophagesRNA Processing & Repair
Housekeeping
BRD7, CCDC59, CCT4, CNDP2, EIF3J, EIF5B, EMC4, EPRS1 +31 moreView in SCUBA
Mucosal-associated invariant T cellActin Cytoskeletal Remodeling
Cytoskeletal
ANXA6, CAP1, CASP1, CCT5, DEF6, FGD3, GIMAP6, HNRNPF +7 more
Natural Killer cellsOxidative Stress Response
Stress
BANF1, CCDC167, CHCHD2, HINT1, HMGN1, HNRNPF, NPM1, PA2G4 +2 moreView in SCUBA

About the gene

SynonymsCCT6, Cctz, HTR3, TCP20, TCPZ, TTCP20
Chromosome7: 56051685-56063989
Predicted locationIntracellular
Essential geneYes
Protein classEssential proteins, Plasma proteins, Predicted intracellular proteins
Molecular functionChaperone, Hydrolase

Function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance.

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.