GNL3 — G protein nucleolar 3
GNL3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
GNL3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB activation TCR/AP1/NFKb pathway | ABCF1, BCL2A1, BUD23, BZW2, CALR, CEBPZ, DDX21, DENND4A +21 more | View in SCUBA |
| Endothelial | Proteasomal Degradation Protein processing & ER | HACD3, MRPL36, NME4, NUDT5, PON2, PSMA1, PSMB5, PSMC1 +3 more | View in SCUBA |
| Hematopoietic progenitor cells | Ribosome Biogenesis Housekeeping | DDX21, DKC1, HNRNPAB, LRPPRC, NOLC1, NOP56, NOP58, PA2G4 +2 more | |
| Innate lymphoid cells | DNA Damage Response Stress | ANP32E, CCT6A, CLTB, FGFR1OP2, HNRNPF, JPT1, MRPS6, PDCD10 +7 more | View in SCUBA |
| Macrophages | RNA Splicing Regulation Housekeeping | ABCF1, CDC42SE1, CDC5L, CDV3, CEBPZ, DNAJC7, DYNC1LI1, FGFR1OP2 +13 more | View in SCUBA |
| Natural Killer cells | NK Cell Activation activation | AKAP9, AKIRIN1, ALG13, DDX24, EIF1AX, ETF1, EZR, PPP1CB +2 more | View in SCUBA |
About the gene
| Synonyms | C77032, E2IG3, MGC800, NS |
|---|---|
| Chromosome | 3: 52681156-52694497 |
| Predicted location | Intracellular |
| Essential gene | Yes |
| Protein class | Essential proteins, Predicted intracellular proteins |
Function
May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.