TRIB2 — Tribbles pseudokinase 2
TRIB2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
TRIB2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | NF-kB feedback TCR/AP1/NFKb pathway | ADTRP, AKAP5, CDIP1, CDKN2A, CLEC7A, INPP1, MAP3K5, N4BP1 +8 more | View in SCUBA |
| Hematopoietic progenitor cells | Regulatory T-cell State Lymphcyte development | CLEC2D, CYTIP, DDIT4, DOCK10, GSTA4, JCHAIN, MDFIC, MEF2A +9 more |
About the gene
| Synonyms | GS3955, TRB2 |
|---|---|
| Chromosome | 2: 12716910-12742734 |
| Predicted location | Membrane |
| Essential gene | No |
| Protein class | Enzymes, Predicted membrane proteins |
| Molecular function | Protein kinase inhibitor |
Function
Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.