Regulatory T-cell State
Gene co-expression module in Hematopoietic progenitor cells
| Category | Lymphcyte development |
|---|---|
| Genes | 18 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 18 genes have a known function matching the annotation |
Why this annotation
DDIT4/REDD1 (mTOR inhibitor, stress-induced), STK17A/B (DRAK kinases, stress/apoptosis), TNFRSF18 (GITR, Treg marker), TNFRSF4 (OX40, T-cell costimulation/Treg), JCHAIN (immunoglobulin J-chain, plasma/B-cell differentiation), TRIB2 (stress-responsive pseudokinase, also in T-cell differentiation), CYTIP (cytohesin-interacting protein, lymphocyte), MEF2A (T/NK TF), DOCK10 (lymphocyte Rac GEF), CLEC2D (NK receptor ligand), RUNX2 (also expressed in lymphoid progenitors under stress). The combination of mTOR stress response (DDIT4, STK17A/B) with lymphocyte differentiation factors (TNFRSF18, TNFRSF4, MEF2A, JCHAIN) suggests a stressed or activated lymphocyte/regulatory T-cell differentiation state in the context of the broader lymphocyte neighborhood.
Genes
CLEC2D, CYTIP, DDIT4, DOCK10, GSTA4, JCHAIN, MDFIC, MEF2A, NEGR1, NPTX2, RASD1, RUNX2, STK17A, STK17B, TNFRSF18, TNFRSF4, TRIB2, ZNF217
Most correlated modules
- T/NK Cell Identity · correlation 0.90
- Lymphocyte Signaling · correlation 0.88
- Naive B Cell · correlation 0.85
- Lymphoid Progenitor TFs · correlation 0.82
- Dendritic Cell Progenitor · correlation 0.76
- ILC/NK Development · correlation 0.76
- MHC-I Antigen Presentation · correlation 0.74
- ILC2-like State · correlation 0.71
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.