MDFIC — MyoD family inhibitor domain containing
MDFIC belongs to a gene co-expression module in 7 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
MDFIC's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | TNF/NF-kB activation TCR/AP1/NFKb pathway | BIRC3, DUSP10, GABARAPL1, HNRNPC, LUZP1, NSUN6, PMAIP1, RBBP8 +6 more | View in SCUBA |
| Gamma-delta T cells | T Cell Migration migration & adhesion | BCL2, BPNT2, CCDC88B, DNM2, EDC4, GMDS, LRRC58, MARK3 +14 more | |
| Hematopoietic progenitor cells | Regulatory T-cell State Lymphcyte development | CLEC2D, CYTIP, DDIT4, DOCK10, GSTA4, JCHAIN, MEF2A, NEGR1 +9 more | |
| Innate lymphoid cells | Endosomal Trafficking Protein processing & ER | ARL14EP, CCDC90B, CLINT1, ESF1, MDM4, MPHOSPH8, NRIP1, NSA2 +11 more | View in SCUBA |
| Lymphatic endothelial | Collecting Lymphatic Identity migration & adhesion | CCDC141, EFNB2, EPB41, FBXO34, FGD6, GUCY1A1, ITGA6, NAV1 +13 more | View in SCUBA |
| Macrophages | RNA Processing Transport Housekeeping | BCL2, CDYL, CPSF6, DHX15, DHX9, EFR3A, EXOC1, FBXO38 +18 more | View in SCUBA |
| Natural Killer cells | Hypoxia Response Stress | ANKRD28, ATP8B4, EPAS1, HIP1, LPIN1, MAML3, RGS1, RHOQ +2 more | View in SCUBA |
About the gene
| Synonyms | HIC, MDFIC1 |
|---|---|
| Chromosome | 7: 114922094-115019917 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins |
| Biological process | Host-virus interaction, Transcription, Transcription regulation |
Function
Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (By similarity). Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. Involved in the development of lymphatic vessel valves (By similarity). Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix. Regulates the activity of mechanosensitive Piezo channel. (Microbial infection) Modulates the expression from viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.