ZFPM2 — Zinc finger protein, FOG family member 2
ZFPM2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZFPM2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Neural-crest Fibroblast Developmental | AMIGO2, C1orf54, CENPW, DCLK1, FLRT2, FOXP2, IGFBP4, KIAA0408 +8 more | View in SCUBA |
| Lymphatic endothelial | Actin-based Migration Cytoskeletal | AUTS2, GAS7, MGAT5, NHSL1, PAN3, PCCA, PPP6R3, TRIO | View in SCUBA |
About the gene
| Synonyms | FOG2, hFOG-2, ZC2HC11B, ZNF89B |
|---|---|
| Chromosome | 8: 104590733-105804539 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Predicted intracellular proteins, Transcription factors |
| Molecular function | Activator, DNA-binding, Repressor |
| Biological process | Differentiation, Gonadal differentiation, Transcription, Transcription regulation |
Function
Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2 (By similarity).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.