AUTS2 — Activator of transcription and developmental regulator AUTS2
AUTS2 belongs to a gene co-expression module in 5 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AUTS2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytokine signaling Immune regulation | ABCB1, ARHGEF40, COLQ, DSE, ERN1, GPR65, IFI44, IFNGR1 +12 more | View in SCUBA |
| Gamma-delta T cells | TCR Threshold Regulation TCR Signaling | AGO2, ATP8A1, CMIP, CNOT6L, CSNK1D, FOXO1, GSPT1, MAP3K8 +8 more | |
| Lymphatic endothelial | Actin-based Migration Cytoskeletal | GAS7, MGAT5, NHSL1, PAN3, PCCA, PPP6R3, TRIO, ZFPM2 | View in SCUBA |
| Mucosal-associated invariant T cell | T cell Quiescence T cell maturation | AGO2, BCL6, BRD1, CSNK1D, DHCR7, FOXO1, GABPB1, GAL3ST2 +13 more | |
| Natural Killer cells | TGF-beta Response Immune regulation | ANKRD9, CDK17, GNA13, MTFP1, N4BP3, RAB5IF, RBM38, TAMALIN +2 more | View in SCUBA |
About the gene
| Synonyms | FBRSL2, KIAA0442 |
|---|---|
| Chromosome | 7: 69598296-70793506 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins |
| Biological process | Transcription, Transcription regulation |
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. The PRC1-like complex that contains PCGF5, RNF2, CSNK2B, RYBP and AUTS2 has decreased histone H2A ubiquitination activity, due to the phosphorylation of RNF2 by CSNK2B. As a consequence, the complex mediates transcriptional activation. In the cytoplasm, plays a role in axon and dendrite elongation and in neuronal migration during embryonic brain development. Promotes reorganization of the actin cytoskeleton, lamellipodia formation and neurite elongation via its interaction with RAC guanine nucleotide exchange factors, which then leads to the activation of RAC1 (By similarity)
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.