Actin-based Migration
Gene co-expression module in Lymphatic endothelial
| Category | Cytoskeletal |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes TRIO (Rho/Rac GEF driving actin remodeling and cell migration), NHSL1 (Nck-associated lamellipodia regulator), and GAS7 (actin bundling) define an actin cytoskeletal/migratory program. MGAT5 modulates integrin-mediated migration via N-glycosylation. AUTS2 has cytoskeletal regulatory roles. The module is uniformly expressed at low levels across LEC subsets, consistent with a basal migratory regulatory program. Neighbor context: this module sits near M92 (formin/lamellipodin-driven migration) and M38 (MAPK/actin), reinforcing a cytoskeletal/migratory neighborhood.
Genes
AUTS2, GAS7, MGAT5, NHSL1, PAN3, PCCA, PPP6R3, TRIO, ZFPM2
Most correlated modules
- Rho/Ras GTPase Regulation · correlation 0.97
- Focal Adhesion Migration · correlation 0.97
- Hippo-Adhesion Signaling · correlation 0.96
- Chromatin Remodeling · correlation 0.96
- Inflammatory cAMP Response · correlation 0.95
- Polarized Vesicle Trafficking · correlation 0.95
- Cilia Centrosome Program · correlation 0.94
- Lipid Metabolic Regulation · correlation 0.92
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.