Neural-crest Fibroblast
Gene co-expression module in Fibroblasts
| Category | Developmental |
|---|---|
| Genes | 17 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 17 genes have a known function matching the annotation |
Why this annotation
Hub genes include NRP1 (axon guidance co-receptor), FOXP2 (developmental TF), MAOB (monoamine catabolism), FLRT2 (fibronectin leucine-rich repeat, axon guidance), DCLK1 (neuronal kinase), ZFPM2 and MEIS1 (developmental TFs). This combination points to a neural-crest-like or deep-layer fibroblast subtype with developmental transcription factor activity. Upregulated in CD inflammation, suggesting a reactive state of this subpopulation.
Genes
AMIGO2, C1orf54, CENPW, DCLK1, FLRT2, FOXP2, IGFBP4, KIAA0408, MAOB, MEIS1, NRP1, PDE3A, PID1, RBM24, RERG, TPST1, ZFPM2
Most correlated modules
- BMP-antagonizing Fibroblast · correlation 0.89
- Submucosal Fibroblast · correlation 0.81
- Complement-producing Fibroblast · correlation 0.78
- Wnt-niche Fibroblast · correlation 0.77
- Inflammation-activated ECM · correlation 0.73
- Subepithelial Fibroblast Identity · correlation 0.72
- CD34+ Quiescent Fibroblast · correlation 0.71
- Quiescent Stromal Identity · correlation 0.65
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.