ZFYVE9 — Zinc finger FYVE-type containing 9
ZFYVE9 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZFYVE9's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell signaling T cell development | AFF3, PELI2, RASGRF2, RNF130, TESPA1, TRIM44, ZNF506 | View in SCUBA |
| Monocytes | Innate Immune Transcription Innate immunity | CARD19, COG3, CSNK1E, ELF4, EXTL3, PCIF1, RBM38, SMIM3 | View in SCUBA |
About the gene
| Synonyms | MADHIP, PPP1R173, SARA, SMADIP |
|---|---|
| Chromosome | 1: 52142089-52348671 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Receptor |
Function
Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.