AFF3 — ALF transcription elongation factor 3
AFF3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
AFF3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD19⁺ B cells | B cell identity TFs B cell maturation | APLP2, C16orf74, FOXP1, IGHM, PLEKHG1, RCSD1, TSPAN13, WASHC4 | View in SCUBA |
| CD4⁺ T cells | T cell signaling T cell development | PELI2, RASGRF2, RNF130, TESPA1, TRIM44, ZFYVE9, ZNF506 | View in SCUBA |
| Fibroblasts | Intestinal Fibroblast Identity Developmental | ABR, ATP8A1, ATP9A, CAMK4, DSE, ENPP2, GLP2R, MRPS6 +7 more | View in SCUBA |
| Hematopoietic progenitor cells | Lymphoid Progenitor TFs Lymphcyte development | ADAM28, ANKRD44, CYFIP2, CYLD, HLA-DMB, MEF2C, PDE7A, RNASEH2B +4 more | |
| Innate lymphoid cells | IFN-driven ILC1 Activation Inflammation | AGPAT5, AKIRIN2, APMAP, ARF6, ARHGEF1, DNAJC1, DYNLT3, ELOVL5 +21 more | View in SCUBA |
| Mucosal-associated invariant T cell | MAIT Cell Identity T cell maturation | DDX3Y, DKK3, DSE, EPAS1, FKBP5, FYN, GLIPR1, H1-10 +16 more |
About the gene
| Synonyms | LAF4, MLLT2-like |
|---|---|
| Chromosome | 2: 99545419-100192428 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Cancer-related genes, Disease related genes, Predicted intracellular proteins |
| Molecular function | Activator, DNA-binding |
| Biological process | Transcription, Transcription regulation |
Function
Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double- stranded DNA
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.