RASGRF2 — Ras protein specific guanine nucleotide releasing factor 2
RASGRF2 belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RASGRF2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | T cell signaling T cell development | AFF3, PELI2, RNF130, TESPA1, TRIM44, ZFYVE9, ZNF506 | View in SCUBA |
| Endothelial | Endothelial Junction Identity Endothelial cell development | ADGRF5, AKAP13, CDH5, CXCL12, DENND5A, FGF12, FURIN, HSPA12B +13 more | View in SCUBA |
| Gamma-delta T cells | TCR Signal Regulation TCR Signaling | ADORA2A, ANO9, CAMK4, CASK, CCR5, CD84, CDC14A, CXCR6 +22 more | |
| Mucosal-associated invariant T cell | RAS-GEF Signaling TCR Signaling | ASCC3, FBXW7, GPATCH8, HERC1, RASGRP1, TLK1, TNRC6B, TRAPPC9 +2 more |
About the gene
| Synonyms | GRF2, Ras-GRF2 |
|---|---|
| Chromosome | 5: 80960363-81230162 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins, RAS pathway related proteins |
| Molecular function | Calmodulin-binding, Guanine-nucleotide releasing factor |
Function
Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.