PCIF1 — Phosphorylated CTD interacting factor 1
PCIF1 belongs to a gene co-expression module in 3 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
PCIF1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Gamma-delta T cells | Hypoxia Stress Response Stress | ARIH2, BNIP2, C9orf78, CHD4, FBXO7, HIF1A, HNRNPH1, JADE1 +16 more | |
| Monocytes | Innate Immune Transcription Innate immunity | CARD19, COG3, CSNK1E, ELF4, EXTL3, RBM38, SMIM3, ZFYVE9 | View in SCUBA |
| Mucosal-associated invariant T cell | TGF-beta Response Immune regulation | ABCA1, ARL4C, ARRDC2, CD48, DDX47, DNLZ, ERGIC1, FMNL1 +21 more |
About the gene
| Synonyms | bA465L10.1, C20orf67, CAPAM, PPP1R121 |
|---|---|
| Chromosome | 20: 45934683-45948023 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins |
| Molecular function | Methyltransferase, Transferase |
Function
Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs. Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.