ZNRF2 — Zinc and ring finger 2
ZNRF2 belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ZNRF2's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Chromatin transcription regulation DNA/chromatin regulation | ADAM10, CIRBP, CLIP1, CUL9, GRPEL2, HBP1, KDM2A, NCOA3 +10 more | View in SCUBA |
| Gamma-delta T cells | Chromatin-Splicing Regulation DNA/chromatin regulation | ANKRD11, BOD1L1, CAMLG, CEBPB, EAPP, FMR1, KMT2B, MED10 +13 more |
About the gene
| Synonyms | RNF202 |
|---|---|
| Chromosome | 7: 30284597-30367689 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Transferase |
| Biological process | Ubl conjugation pathway |
Function
E3 ubiquitin-protein ligase that plays a role in the establishment and maintenance of neuronal transmission and plasticity. Ubiquitinates the Na(+)/K(+) ATPase alpha-1 subunit/ATP1A1 and thereby influences its endocytosis and/or degradation. Acts also as a positive regulator of mTORC1 activation by amino acids, which functions upstream of the V-ATPase and of Rag-GTPases. In turn, phosphorylation by mTOR leads to its inhibition via targeting to the cytosol allowing a self-regulating feedback mechanism.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.