B cell identity TFs
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes AFF3 and FOXP1 are key B cell transcription factors involved in B cell development and germinal center/maturation programs. IGHM (naive/IgM B cell marker), RCSD1, TSPAN13 are also B-cell associated. Core coherence and uniform B-cell expression support a B cell developmental/identity program.
Genes
AFF3, APLP2, C16orf74, FOXP1, IGHM, PLEKHG1, RCSD1, TSPAN13, WASHC4
Most correlated modules
- BCR signaling/maturation · correlation 0.79
- Naive B cell · correlation 0.70
- Notch signaling · correlation 0.66
- Naive B-cell identity · correlation 0.63
- B cell identity · correlation 0.62
- NFkB/MAPK activation · correlation 0.60
- Germinal center B-cell · correlation 0.51
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.