B cell identity
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 9 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 5 of 9 genes have a known function matching the annotation |
Why this annotation
Hub genes are canonical B cell surface/identity markers: CD37 (tetraspanin), TNFRSF13C (BAFF-R, B cell survival), plus ITM2B, GNG7, DRAM2. TNFRSF13C and CD37 mark mature B cell identity and survival signaling. This is a B cell identity/maturation/survival module, core coherence.
Genes
C12orf42, CD37, DRAM2, GNG7, ITM2B, PRICKLE1, RBMS1, SAV1, TNFRSF13C
Most correlated modules
- B cell quiescence · correlation 0.85
- Adhesion/Migration · correlation 0.83
- Chromatin Regulation · correlation 0.78
- AP-1 Immediate Early · correlation 0.74
- Hypoxia/metabolic stress · correlation 0.72
- Notch signaling · correlation 0.66
- MHC-I Antigen Presentation · correlation 0.65
- Plasma cell secretory · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.