Naive B-cell identity
Gene co-expression module in CD19⁺ B cells
| Category | B cell maturation |
|---|---|
| Genes | 16 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 16 genes have a known function matching the annotation |
Why this annotation
Clear B-cell identity / naive-follicular B-cell module: CD79B (BCR component), TCL1A (naive B-cell marker), P2RX5, IRF8 (B-cell transcription factor), HLA-DOB, plus phagocyte/NADPH oxidase NCF1 and ALOX5AP. Core members CD79B, TCL1A, IRF8, P2RX5 anchor a B-cell developmental/maturation identity signature. Induced with inflammation and reduced with treatment in CD. Uniform across B cells.
Genes
ALOX5AP, CD79B, HLA-DOB, IRF8, NCF1, P2RX5, PLEKHF2, SEC62, SIAH2, SORL1, STAG3, STRBP, TCL1A, TMEM123, TMEM243, ZCCHC7
Most correlated modules
- Germinal center B-cell · correlation 0.86
- B-cell activation signaling · correlation 0.80
- Somatic Hypermutation · correlation 0.80
- Dark-zone GC B-cell · correlation 0.80
- BCR signaling/maturation · correlation 0.79
- MHC-II antigen presentation · correlation 0.78
- Germinal Center Maturation · correlation 0.78
- B-cell signaling regulators · correlation 0.68
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.