Translation machinery
Gene co-expression module in CD4⁺ T cells
| Category | Housekeeping |
|---|---|
| Genes | 11 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes are translation initiation/elongation factors (EIF3G, EIF3K, EIF3D, EEF2), ribosomal protein RPL15, RACK1, BTF3, and OxPhos components COX4I1, ATP5PO. This is a housekeeping translation/biosynthesis module with uniform expression and high detection, classic ambient/housekeeping signature.
Genes
ATP5PO, BTF3, COX4I1, EEF2, EIF3D, EIF3G, EIF3K, MZT2B, RACK1, RPL15, UBXN1
Most correlated modules
- Oxidative Phosphorylation · correlation 0.73
- Leukocyte adhesion signaling · correlation 0.68
- Ribosome biogenesis · correlation 0.65
- Naive T quiescence · correlation 0.41
- Naive T cell · correlation 0.38
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.