Type I Interferon
Gene co-expression module in CD8⁺ T cells
| Category | Inflammation |
|---|---|
| Genes | 12 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 12 of 12 genes have a known function matching the annotation |
Why this annotation
This is a textbook Type I interferon response module with near-perfect coherence. All 12 genes are canonical ISGs: IFI6, ISG15, MX1, OAS1, USP18, IRF7, IFI44, IFI35, IFI44L, OAS3, EPSTI1 are directly induced by IFN-α/β via ISGF3 (IRF9/STAT1/STAT2). LGALS9 is also IFN-inducible and involved in immune regulation. USP18 is a key negative regulator of the IFN pathway and an ISG itself. IRF7 is the master transcription factor for type I IFN induction. This module has the highest coherence in the batch, reflecting a tightly co-regulated antiviral transcriptional program. In the CRC tumor context, this likely reflects a subset of CD8 T cells exposed to type I IFN signals from the tumor microenvironment.
Genes
EPSTI1, IFI35, IFI44, IFI44L, IFI6, IRF7, ISG15, LGALS9, MX1, OAS1, OAS3, USP18
Most correlated modules
- Antiviral ISG Response · correlation 0.92
- Type I Interferon · correlation 0.88
- Interferon-stimulated Genes · correlation 0.80
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.