OAS3 — 2'-5'-oligoadenylate synthetase 3
OAS3 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
OAS3's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Type I Interferon Inflammation | EPSTI1, IFI35, IFI44, IFI44L, IFI6, IRF7, ISG15, LGALS9 +3 more | View in SCUBA |
| Endothelial | Type I Interferon Inflammation | CMPK2, HELZ2, IFI44, IFI44L, IFI6, IFIT1, IFIT2, IFIT3 +9 more | View in SCUBA |
| Fibroblasts | Type I Interferon Inflammatory | APOL6, BATF2, CXCL10, GBP1, IFI44L, IFIT2, IFIT3, ISG15 +6 more | View in SCUBA |
| Macrophages | Type I Interferon Antiviral | CCL8, CMPK2, HELZ2, IFI27, IFI44, IFI44L, IFI6, IFIT1 +13 more | View in SCUBA |
| Monocytes | Type I Interferon Response Antiviral | EPSTI1, IFI44, IFI44L, IFI6, IRF7, MX1, OAS2, PARP12 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | CMPK2, HELZ2, HERC6, IFIT1, LAMP3, LGALS9, MX2, PLSCR1 +2 more |
About the gene
| Chromosome | 12: 112938051-112976460 |
|---|---|
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Predicted intracellular proteins |
| Molecular function | Nucleotidyltransferase, RNA-binding, Transferase |
| Biological process | Antiviral defense, Immunity, Innate immunity |
Function
Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.