IFI44L — Interferon induced protein 44 like
IFI44L belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
IFI44L's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD8⁺ T cells | Type I Interferon Inflammation | EPSTI1, IFI35, IFI44, IFI6, IRF7, ISG15, LGALS9, MX1 +3 more | View in SCUBA |
| Endothelial | Type I Interferon Inflammation | CMPK2, HELZ2, IFI44, IFI6, IFIT1, IFIT2, IFIT3, IFIT5 +9 more | View in SCUBA |
| Fibroblasts | Type I Interferon Inflammatory | APOL6, BATF2, CXCL10, GBP1, IFIT2, IFIT3, ISG15, MX1 +6 more | View in SCUBA |
| Glial cells | IFN-gamma Effector Program Inflammation | APOL1, APOL2, GBP1, IDO1, IL18BP, IL32, LAP3, ODF3B +5 more | View in SCUBA |
| Macrophages | Type I Interferon Antiviral | CCL8, CMPK2, HELZ2, IFI27, IFI44, IFI6, IFIT1, IFIT2 +13 more | View in SCUBA |
| Monocytes | Type I Interferon Response Antiviral | EPSTI1, IFI44, IFI6, IRF7, MX1, OAS2, OAS3, PARP12 +1 more | View in SCUBA |
| Mucosal-associated invariant T cell | Type I Interferon Inflammation | DDX60, DDX60L, DTX3L, EIF2AK2, EPSTI1, GBP2, GBP4, HERC5 +18 more | |
| Pericytes | Type I Interferon Inflammatory | IFI16, IFI6, MX1, PPIC, RCN1, SP100, TNFRSF1A, XAF1 | View in SCUBA |
About the gene
| Synonyms | C1orf29, GS3686, TLDC5B |
|---|---|
| Chromosome | 1: 78619902-78646145 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Biological process | Antiviral defense |
Function
Type I interferon-stimulated gene (ISG) that plays a critical role in antiviral and antibacterial activity. During bacterial infection, promotes macrophage differentiation and facilitates inflammatory cytokine secretion. Plays a role in the control of respiratory syncytial virus/RSV infection, reducing the ability of the virus to replicate. Exhibits a low antiviral activity against hepatitis C virus. Also acts as a feedback regulator of IFN responses by negatively regulating IKBKB and IKBKE kinase activities through interaction with FKBP5.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.